Nicotine impact on melanogenesis and antioxidant defense system in HEMn-DP melanocytes
نویسندگان
چکیده
منابع مشابه
Fluphenazine and Perphenazine Impact on Melanogenesis and Antioxidant Enzymes Activity in Normal Human Melanocytes
Fluphenazine and perphenazine as a phenothiazine-class antipsychotic drugs are widely used to treat psychoses and schizophrenia, however their use is associated with significant side effects such as extrapyramidal symptoms as well as ocular and skin disorders. The aim of this study was to examine the effect of fluphenazine and perphenazine on cell viability, melanogenesis and antioxidant defens...
متن کاملIMPACT OF GENTAMICIN ON ANTIOXIDANT ENZYMES ACTIVITY IN HEMn-DP CELLS.
Aminoglycoside antibiotics, including gentamicin, are widely used clinically in treatment of bacterial infections. Unfortunately, their side effects, especially nephrotoxicity and ototoxicity remain a problem. It is known that aminoglycoside antibiotics bind well to melanin biopolymer, but the relation between their affinity to melanin and ototoxicity is not well documented. The aim of this wor...
متن کاملAntioxidant Defense and UV-Induced Melanogenesis: Implications for Melanoma Prevention
Ultraviolet radiation (UVR) has been implicated as a major environmental factor in the pathogenesis of photoaging and skin cancers including melanoma. Hypermelanosis induced by UVR has been previously suggested to associate with melanomageneis, although the role of UVR in the development of melanoma is complicated since melanogenesis may depend on several factors such as skin type, genetic infl...
متن کاملMelanogenesis by human uveal melanocytes in vitro.
PURPOSE To study melanogenesis by cultured human uveal melanocytes, and the relationship between melanin production by uveal melanocytes in vitro with the degree of iris pigmentation in vivo. METHODS Melanin content, melanin production, and tyrosinase activity of cultured uveal melanocytes derived from eyes of various iris color were measured at different stages of cultivation. RESULTS Cult...
متن کاملPimecrolimus increases the melanogenesis and migration of melanocytes in vitro
Vitiligo is an intriguing depigmentary disorder and is notoriously difficult to be treated. The ultimate goal of vitiligo treatment is to replenish the lost melanocytes by immigration from hair follicle and to restore the normal function of melanogenesis by residual melanocytes. There are two types of topical calcineurin inhibitors called tacrolimus and pimecrolimus, and are recommended as the ...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biochemistry
سال: 2014
ISSN: 0300-8177,1573-4919
DOI: 10.1007/s11010-014-2116-1